Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Organization of the Brain01:30

Organization of the Brain

937
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
937
Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

5.6K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
5.6K
Brain Imaging01:14

Brain Imaging

278
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
278
Association Areas of the Cortex01:21

Association Areas of the Cortex

5.7K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.7K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

2.2K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.2K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

2.0K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain regions with gestational age differences mediate cognition in adolescents born very premature.

Communications biology·2026
Same author

Environmental Enrichment Remodels Brain Structural and Behavioral Plasticity in Restricted and Repetitive C58 Mouse Models.

bioRxiv : the preprint server for biology·2026
Same author

Comparative Mapping of Functional and Structural Homologies in the Pig and Human Brain.

bioRxiv : the preprint server for biology·2026
Same author

Microstructural Disruption of the Forceps Minor in Schizophrenia: A Potential Clinical Imaging Biomarker Using Translational DTI.

bioRxiv : the preprint server for biology·2026
Same author

Deciphering multiway multiscale brain network connectivity from birth to 6 months.

Communications biology·2026
Same author

LINKING BRAIN ENTROPY TO MOLECULAR AND CELLULAR ARCHITECTURE IN PSYCHOSIS.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Aug 16, 2025

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.1K

Functional Connectome of the Human Brain with Total Correlation.

Qiang Li1, Greg Ver Steeg2, Shujian Yu3

  • 1Image Processing Laboratory, University of Valencia, 46980 Valencia, Spain.

Entropy (Basel, Switzerland)
|December 23, 2022
PubMed
Summary

This study introduces Total Correlation for mapping brain connectivity, offering a novel multivariate approach beyond traditional methods. This new network analysis shows promise for identifying brain alterations and aiding in disease discovery.

Keywords:
CorExTotal CorrelationbiomarkersfMRIfunctional connectivitylarge-scale connectome

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.3K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

5.0K

Related Experiment Videos

Last Updated: Aug 16, 2025

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.1K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.3K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

5.0K

Area of Science:

  • Neuroscience
  • Network Science
  • Biomarker Discovery

Background:

  • Conventional brain connectivity analysis relies on pairwise measures like correlation or mutual information.
  • Total Correlation offers a multivariate approach to capture complex functional connectivity among brain regions.

Purpose of the Study:

  • To infer a large-scale, whole-brain connectivity network using Total Correlation.
  • To validate this network as a potential biomarker for brain alterations.
  • To explore its utility in discovering brain diseases.

Main Methods:

  • Utilized Correlation Explanation (CorEx) to estimate Total Correlation.
  • Validated CorEx estimates against ground truth values for Total Correlation and clustering.
  • Inferred large-scale connectivity networks from open fMRI datasets.

Main Results:

  • CorEx-based Total Correlation and clustering estimates were found to be trustworthy.
  • The inferred whole-brain network aligns with existing neuroscience findings.
  • The method identified additional relationships beyond pairwise brain region interactions.
  • Connectivity graphs derived from Total Correlation demonstrated effectiveness in aiding disease discovery.

Conclusions:

  • Total Correlation provides a robust, multivariate method for whole-brain network inference.
  • These networks serve as promising biomarkers for detecting brain alterations.
  • The approach enhances the discovery of neurological diseases through advanced connectivity analysis.