Related Experiment Video
Updated: Aug 16, 2025
05:53
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
16.7K
Association between Perceived Health-Related Quality of Life and Depression with Frailty in the FRASNET Study
Giulia B Delli Zotti1, Lorena Citterio2, Sara Farinone1
1Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
International Journal of Environmental Research and Public Health
|December 23, 2022
Summary
Frailty in older adults is influenced by psychological factors like quality of life and depression. Assessing these aspects can help identify at-risk individuals for better health outcomes.
Area of Science:
- Gerontology
- Psychiatry
- Genetics
Background:
- Frailty is a significant challenge in aging populations, with its phenotype not yet fully defined.
- Understanding factors contributing to frailty is crucial for identifying at-risk older adults.
Purpose of the Study:
- To investigate the relationship between psychological factors, quality of life, and frailty in a geriatric population.
- To identify key indicators for predicting frailty and adverse outcomes in aging individuals.
Main Methods:
- Observational cohort study (FRASNET) of 1204 Italian geriatric subjects (frail, pre-frail, robust).
- Conditional inference tree analysis to determine variables influencing frailty.
- Correlation analysis between quality of life scores, depression scales, and biomarkers (CXCL10).
- Genetic association study of the rs7567647 variant in the FN1 gene with frailty.
Main Results:
- Psychological variables significantly influence frailty.
- Physical component of quality of life (SF-36-PCS) and presence of a caregiver were predominant predictors of frailty.
- Frailty is associated with lower mental quality of life (SF-36-MCS), depression (GDS-15), leisure activities, and education level.
- SF-36-PCS correlated with CXCL10 levels, indicating a link between inflammation, senescence, and physical frailty.
- The rs7567647 variant in the FN1 gene was significantly associated with frailty.
Conclusions:
- Perception of health-related quality of life and subclinical depression are key contributors to frailty.
- Assessment of QoL and depression can improve the identification of older patients at higher risk of adverse outcomes.
- Psychological and genetic factors play a role in the complex phenotype of frailty.
Related Concept Videos
02:12Relationship Formation
40.3K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
40.3K
01:18Factors Affecting Illness
4.3K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.3K
01:30Stress and Mental Health
195
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
195
01:18Depression: Overview
317
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
317
01:27Depressive Disorders: Etiology
152
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
152
01:29Assessment of the Gastrointestinal System II: Health Perception Pattern
152
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
152