Obesity as a Risk Factor for Breast Cancer-The Role of miRNA

Area of Science:

• Oncology
• Metabolic Disorders
• Molecular Biology

Background:

• Breast cancer (BC) is the most prevalent cancer in women globally, with rising incidence.
• Increasing risk factors like obesity and metabolic disorders necessitate understanding BC pathogenesis.
• Obesity is a significant factor initiating and promoting breast cancer development in women.

Purpose of the Study:

• To review the mechanisms by which obesity elevates breast cancer risk.
• To elucidate the role of obesity-induced inflammation and metabolic dysfunction in breast cancer initiation.
• To explore the involvement of microRNAs (miRNAs) in obesity-related breast cancer pathogenesis.

Main Methods:

• Literature review focusing on obesity, inflammation, metabolic disorders, and microRNAs in breast cancer.
• Analysis of current research on the molecular pathways linking obesity to breast cancer.
• Synthesis of information on microRNA regulation in breast cancer development.

Main Results:

• Obesity triggers inflammatory processes that disrupt cellular metabolism and hormonal balance.
• These metabolic and hormonal disturbances are critical in the pathogenesis of breast cancer.
• MicroRNAs (miRNAs) play a significant regulatory role in these obesity-driven cancer mechanisms.

Conclusions:

• Obesity is a critical risk factor for breast cancer, acting through inflammatory and metabolic pathways.
• MicroRNAs (miRNAs) are implicated as potential biomarkers for breast cancer risk and progression.
• Targeting miRNA pathways presents a promising avenue for novel anti-cancer therapies for breast cancer.