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The Mutual Relationship between Glycosylation and Non-Coding RNAs in Cancer and Other Physio-Pathological Conditions

Martina Duca1, Nadia Malagolini1, Fabio Dall'Olio1

  • 1Department of Experimental, Diagnostic and Specialty Medicine (DIMES), General Pathology Building, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.

International Journal of Molecular Sciences
|December 23, 2022
PubMed

Insights

Glycosylation and non-coding RNAs (ncRNAs) are stochastic processes that regulate protein activity. This review explores their interconnected roles in cancer and other conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Glycosylation is a key post-translational modification affecting protein and lipid activity.
  • It is a stochastic process influenced by enzyme and substrate abundance.
  • Non-coding RNAs (ncRNAs) regulate gene expression through stochastic interactions.

Purpose of the Study:

  • To review the intricate interplay between ncRNAs and glycosylation.
  • To explore their combined roles in physiological and pathological conditions, particularly cancer.

Main Methods:

  • Literature review and synthesis of existing research on ncRNA-glycosylation interactions.
  • Analysis of regulatory mechanisms involving glycosyltransferases, glycosidases, and ncRNAs.
  • Discussion of implications in cancer and other diseases.

Main Results:

  • Glycosylation and ncRNA regulation are both stochastic processes impacting protein abundance and activity.
  • These two systems are closely interconnected and mutually influence each other.
  • The interplay is critical for cellular functions and disease development.

Conclusions:

  • The ncRNA-glycosylation axis represents a significant regulatory network in biological systems.
  • Understanding this interplay is crucial for developing novel therapeutic strategies for cancer and other diseases.
  • Further research into this interaction promises new insights into disease mechanisms.
Keywords:
glycosylationglycosyltransferasesmiRNAnon-coding RNAssugar antigens

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