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Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an
J F Leeuwenberg1, J van Damme, G M Jeunhomme
1Department of Surgery, University of Limburg, Maastricht, The Netherlands.
The Journal of Experimental Medicine
|October 1, 1987
Abstract:
In conclusion, our observations indicate that the constitutive MHC class I expression is regulated by autocrine production of IFN-beta 1. TNF-alpha acts as an enhancer of the autocrine production of IFN-beta 1, and consequently as an enhancer of the MHC class I expression and viral protection.