Related Experiment Video
Updated: Aug 16, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
Essential Thrombocythemia: One-Center Data in a Changing Disease.
Nicoleta Pirciulescu1, Mihnea-Alexandru Gaman1,2, Marina Mihailescu1
1Department of Clinical Hematology, Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Essential thrombocythemia (ET) patients in Romania are younger and predominantly female. Thrombotic events, influenced by JAK2V617F mutation and leukocyte count, significantly impact survival in these myeloproliferative neoplasm cases.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm.
- ET is characterized by increased platelet counts and carries risks of thrombo-hemorrhagic complications.
- Progression to myelofibrosis or acute myeloid leukemia is a known outcome.
Purpose of the Study:
- To present real-world data on ET cases diagnosed and managed in Romania from 1998-2020.
- To evaluate the impact of thrombotic events on survival in ET patients.
- To identify risk factors associated with thrombosis and survival.
Main Methods:
- Retrospective cohort study of 168 ET patients meeting 2016 WHO criteria.
- Data collected and analyzed from a tertiary hematology reference center.
- Statistical analysis to assess correlations between clinical factors, mutations, thrombosis, and survival.
Main Results:
- Median age at ET diagnosis was 51.8 years, with 66.07% females.
- JAK2V617F mutation found in 60.71% of patients.
- Leukocytosis and JAK2V617F positivity increased thrombosis risk; survival was lower with major thrombosis (14.5 vs. 20.6 years).
Conclusions:
- Romanian ET patients are younger and predominantly female.
- Thrombotic event occurrence is linked to gender, leukocyte count, and JAK2V617F status.
- Survival is influenced by age, JAK2V617F, hypertension, thrombosis, and IPSET score.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Venous Thrombosis I: Introduction
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

