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Fabrication, Acoustic Characterization and Phase Reference-Based Calibration Method for a Single-Sided Multi-Channel

Hiep Xuan Cao1,2, Daewon Jung2, Han-Sol Lee1

  • 1School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea.

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Summary

This study demonstrates a novel ultrasonic actuator for non-contact manipulation of micromachines in medical applications. The calibrated system successfully traps and moves micro-objects using acoustic fields, paving the way for advanced therapeutic tools.

Keywords:
phase calibrationtwin trapultrasonic actuators

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Area of Science:

  • Acoustics
  • Biomedical Engineering
  • Materials Science

Background:

  • Ultrasonic actuators offer label-free, biocompatible, and safe non-contact manipulation for medical therapies.
  • Increasing interest exists in using ultrasonic actuators for precise control of micro-machines in various therapeutic applications.

Purpose of the Study:

  • To design, fabricate, and characterize a 56-channel, 500 kHz single-sided transducer array for enhanced tissue penetration.
  • To calibrate the transducer array using phase reference calibration to improve acoustic field homogeneity and pressure.
  • To demonstrate the capability of trapping and manipulating micro-machines using generated acoustic twin traps.

Main Methods:

  • Design and fabrication of a 56-channel, 500 kHz ultrasonic transducer array.
  • Phase reference calibration to correct for misalignment and phase discrepancies.
  • Acoustic field measurement using a hydrophone and 3D holographic analysis.
  • Demonstration of micro-machine manipulation using optical and ultrasound imaging.

Main Results:

  • Improved homogeneity of acoustic pressure fields around the focal area.
  • Increased maximum acoustic pressure within the twin trap.
  • Successful trapping and manipulation of micro-machines using acoustic power.
  • Validation of the calibrated transducer's performance in generating precise acoustic fields.

Conclusions:

  • The developed ultrasonic actuator, with its calibrated transducer array, effectively manipulates micro-machines via acoustic fields.
  • This research provides a comprehensive study on acoustic actuators, encouraging future applications in medicine.
  • The system's capabilities highlight the potential of acoustics for advanced therapeutic interventions.