Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Work at Heights Training: Conventional Approach with and Without Immersive Virtual Reality Study Protocol.

Methods and protocols·2026
Same author

A Social Justice Approach to Assistive Technology and Well-Being of People With Visual Disabilities in Low- and Middle-Income Countries: Qualitative Narrative Study.

JMIR rehabilitation and assistive technologies·2026
Same author

Challenges and Opportunities of the Human-Centered Design Approach: Case Study Development of an Assistive Device for the Navigation of Persons With Visual Impairment.

JMIR rehabilitation and assistive technologies·2025
Same author

Low-cost gelatin/collagen scaffolds for bacterial growth in bioreactors for biotechnology.

Applied microbiology and biotechnology·2025
Same author

Biocompatibility Evaluation of a Dexamethasone Mucoadhesive Nanosystem: Preclinical and Preliminary Clinical Evaluations.

Current drug delivery·2025
Same author

Evaluation of Biocompatible Materials for Enhanced Mesenchymal Stem Cell Expansion: Collagen-Coated Alginate Microcarriers and PLGA Nanofibers.

Biomolecules·2025

Related Experiment Video

Updated: Jun 24, 2026

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
04:40

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

Published on: July 2, 2017

10.3K

Manufacturing of a Transdermal Patch in 3D Printing.

Isabella Villota1, Paulo César Calvo1, Oscar Iván Campo1

  • 1Biomedical Engineering Research Group-GBIO, Universidad Autónoma de Occidente, Cali 760030, Colombia.

Micromachines
|December 23, 2022
PubMed
Summary

This study introduces a novel 3D-printed microneedle patch for transdermal drug delivery, offering a minimally invasive method for managing diabetes mellitus. The design ensures mechanical stability and efficient fluid flow for potential therapeutic applications.

Keywords:
3D printingfinite element analysismicroneedlestransdermal drug delivery

More Related Videos

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
07:47

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Published on: September 26, 2020

6.7K
Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
08:31

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

4.0K

Related Experiment Videos

Last Updated: Jun 24, 2026

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
04:40

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

Published on: July 2, 2017

10.3K
Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
07:47

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Published on: September 26, 2020

6.7K
Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
08:31

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

4.0K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Endocrinology

Background:

  • Diabetes mellitus impairs glucose metabolism and insulin utilization.
  • Transdermal drug delivery (TDD) offers a minimally invasive alternative to conventional methods.
  • Microneedle (MN) systems integrated into patches present an innovative TDD approach.

Purpose of the Study:

  • To design and analyze a 3D-printed microneedle transdermal patch for drug delivery.
  • To evaluate the mechanical properties and fluid dynamics of the microneedle patch.

Main Methods:

  • Design of a 25-microneedle patch using 3D printing (stereolithography) with biocompatible resin.
  • Finite element analysis (FEA) using ANSYS for mechanical behavior assessment.
  • Flow simulation to determine pressure and velocity requirements for volumetric flow.

Main Results:

  • FEA revealed a Von Mises stress of 18.057 MPa, maximum deformation of 2.179×10-3, and a safety factor of 4.
  • Flow simulation indicated a pressure of 1.084 Pa and fluid velocity of 4.800 m/s are needed for a volumetric flow rate of 4.447×10-5 cm³/s.

Conclusions:

  • The 3D-printed microneedle patch demonstrates suitable mechanical integrity and fluid dynamics for TDD.
  • The study provides critical parameters for developing advanced transdermal drug delivery devices.