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Bidirectional Functional Effects of Staphylococcus on Carcinogenesis
Yuannan Wei1, Esha Sandhu1, Xi Yang2
1Faculty of Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Microorganisms
|December 23, 2022
Summary
Staphylococcus bacteria, including Staphylococcus aureus, are linked to cancer development. This review explores staphylococcal virulence factors and the oncoprotein SND1 in relation to various cancers.
Area of Science:
- Microbiology
- Oncology
- Molecular Biology
Background:
- Staphylococcus, a Gram-positive cocci, includes species like Staphylococcus aureus and epidermidis.
- Cancer patients exhibit higher susceptibility to bacterial and antibiotic-resistant infections.
- Emerging evidence links staphylococcal infections to carcinogenesis.
Purpose of the Study:
- To review basic and clinical evidence on the association between staphylococci and neoplasms.
- To investigate the role of staphylococcal virulence factors and SND1 in various cancers.
Main Methods:
- Literature review of studies on staphylococci and cancer.
- Analysis of staphylococcal virulence factors (e.g., PVL, SEs, SpA, TSST-1).
- Examination of the oncoprotein SND1 (staphylococcal nuclease and Tudor domain-containing 1).
Main Results:
- Staphylococcus employs virulence factors to promote pathogenicity and evade immune responses.
- Staphylococcal nucleases (SNases) are genomic markers for S. aureus.
- SND1, a human homologue of SNases, functions as an oncoprotein.
Conclusions:
- This review is the first to consolidate evidence on staphylococci and cancer.
- Further investigation into staphylococcal roles in breast, skin, oral, and colon cancers is warranted.
- Understanding staphylococcal virulence factors and SND1 is crucial for cancer diagnosis and treatment.
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