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Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics.
Ali A Rabaan1,2,3, Rehab Bukhamsin4, Hajir AlSaihati5
1Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
Molecules (Basel, Switzerland)
|December 23, 2022
Summary
Developing advanced nanotheranostics is crucial for safer, more effective cancer treatment. This review explores metal-based nanotechnologies for improved cancer diagnosis and therapy, addressing limitations of conventional methods.
Area of Science:
- Nanomedicine and Biomedical Engineering
- Materials Science in Oncology
- Translational Cancer Research
Background:
- Conventional cancer therapies (radiotherapy, chemotherapy) face challenges like severe side effects and drug resistance.
- There is an urgent need for novel anticancer treatments that are both effective and safe.
- Nanotheranostics offer a promising approach by integrating diagnostics and therapeutics at the nanoscale.
Purpose of the Study:
- To review the physical characteristics of metallic, functionalized, and hybrid nanotheranostic systems.
- To discuss the clinical advantages and limitations of current cancer nanotheranostics.
- To identify future research directions for enhancing nanotheranostic biocompatibility and clinical viability.
Main Methods:
- Comprehensive review of existing literature on metal-based nanotheranostics.
- Analysis of physical properties, surface chemistry, and shape of various nanotheranostic systems.
- Evaluation of clinical data regarding efficacy, safety, and limitations of nanotheranostics.
Main Results:
- Metal-based nanotheranostics are the most prevalent type, offering integrated diagnosis and treatment.
- Nanotheranostics enable precise imaging, targeted drug delivery, and real-time monitoring of therapeutic response.
- Current nanotheranostics present both significant clinical advantages and notable limitations.
Conclusions:
- Metal-based nanotheranostics represent a key area in cancer nanotheranostics development.
- Further research is needed to improve the biocompatibility and robustness of theranostic nanoparticles for clinical application.
- Enhancing nanotheranostic strategies holds potential for overcoming conventional treatment challenges and improving patient outcomes.
