Versatile Fluorine-Containing Building Blocks: β-CF3-1,3-enynes.
Mingqing Liu1, Zongxiang Yu1, Jingtong Li1
1Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
Molecules (Basel, Switzerland)
|December 23, 2022
Summary
This review highlights the synthesis of valuable organofluorine compounds using beta-trifluoromethyl-1,3-enynes. These building blocks enable the creation of diverse molecules with biologically relevant structures.
Area of Science:
- Fluorine Chemistry
- Organic Synthesis
Background:
- Diversity-oriented synthesis is a key area in fluorine chemistry.
- Beta-trifluoromethyl-1,3-enynes are versatile fluorine-containing building blocks.
- These enynes exhibit unique reactivity for synthesizing complex molecules.
Purpose of the Study:
- To review recent advancements in organofluorine compound synthesis.
- To provide an overview of synthetic strategies utilizing beta-trifluoromethyl-1,3-enynes.
- To highlight the preparation of biologically relevant trifluoromethylated and non-fluorinated compounds.
Main Methods:
- Utilizing beta-trifluoromethyl-1,3-enynes as key synthons.
- Employing various synthetic transformations to access diverse molecular scaffolds.
- Focusing on reactions leading to O-, N-, and S-heterocycles, carboncycles, and polycycles.
Main Results:
- Successful synthesis of numerous value-added organofluorine compounds.
- Access to biologically relevant structural motifs including heterocycles and polycycles.
- Demonstration of the utility of beta-trifluoromethyl-1,3-enynes in constructing complex architectures.
Conclusions:
- Beta-trifluoromethyl-1,3-enynes are powerful building blocks in modern organic synthesis.
- These synthons facilitate the efficient construction of diverse and valuable organofluorine compounds.
- The reviewed synthetic methodologies offer broad applicability in medicinal and materials chemistry.
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