Non-Covalent Reactions Supporting Antiviral Development

Area of Science:

• Pharmaceutical Sciences
• Drug Discovery
• Virology

Background:

• Viruses pose a significant global health threat, necessitating continuous development of effective antiviral therapies.
• Viral evolution into new mutants presents a persistent challenge for healthcare systems worldwide.
• Developing novel antiviral active pharmaceutical ingredients (APIs) is time-consuming and resource-intensive due to extensive safety and efficacy testing.

Purpose of the Study:

• To review current research and marketed antiviral multicomponent systems.
• To discuss strategies for modifying existing APIs to improve physicochemical properties and enhance antiviral activity.
• To provide insights into the opportunities and challenges of solid antiviral drug modifications for future development.

Main Methods:

• Literature review of antiviral multicomponent systems in research and on the market.
• Analysis of different types of antivirals and their counterpart compounds.
• Examination of screening, manufacturing, characterization methods, and property analysis of multicomponent systems.

Main Results:

• Antiviral multicomponent systems represent a promising approach for enhancing drug efficacy and properties.
• Modification of solid structures of existing APIs can accelerate the development of new antiviral treatments.
• The review covers various aspects, including system types, manufacturing, characterization, and pharmacological effects.

Conclusions:

• Developing antiviral multicomponent systems is an efficient strategy compared to de novo drug discovery.
• Solid form modification of existing APIs offers a viable pathway to overcome challenges in antiviral development.
• Further research into antiviral multicomponent systems holds significant potential for combating viral diseases.