Levofloxacin-Niflumate Salt Development as a Strategy for Improving Physicochemical Properties and Modulating...

Area of Science:

• Pharmaceutical Science
• Drug Discovery
• Materials Science

Background:

• Levofloxacin is a potent antibiotic, and niflumic acid is an anti-inflammatory agent.
• Co-administration of levofloxacin and niflumic acid is common, but individual drug properties may limit efficacy.
• Developing novel salt forms can improve physicochemical and therapeutic properties of existing drugs.

Purpose of the Study:

• To synthesize and characterize a new salt of levofloxacin and niflumic acid.
• To enhance the physicochemical properties, antibiotic potency, and anti-inflammatory activity.
• To evaluate the stability and scalability of the novel salt form.

Main Methods:

• Salt synthesis using a 1:1 molar ratio.
• Crystallographic analysis (SCXRD, PXRD) and thermal analysis (DSC).
• Spectroscopic characterization (FTIR), scalability assessment (grinding, hot melt, slurry), stability studies, and biological activity evaluation (antibiotic potency, anti-inflammatory effects).

Main Results:

• A stable multicomponent salt, levofloxacin-niflumate, was successfully synthesized and characterized.
• The slurry method produced a homogeneous powder with desirable structural properties.
• The novel salt exhibited enhanced physical and chemical stability, increased niflumic acid solubility, and improved potency for both drugs.

Conclusions:

• The levofloxacin-niflumate salt represents a promising strategy for improving drug stability and efficacy.
• Enhanced solubility and potency suggest potential for more effective therapeutic applications.
• This development could lead to improved patient compliance due to enhanced drug performance.