Related Experiment Video

Updated: Aug 16, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

265

Renal Proximal Tubular Cells: A New Site for Targeted Delivery Therapy of Diabetic Kidney Disease

Hao Li1, Wenni Dai1, Zhiwen Liu1

  • 1Department of Nephrology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha 410011, Hunan, China.

Pharmaceuticals (Basel, Switzerland)
|December 23, 2022
PubMed

Insights

New targeted drug delivery strategies show promise for treating diabetic kidney disease (DKD). This research focuses on proximal tubule cell-targeted therapies to slow DKD progression and improve patient outcomes.

Area of Science:

  • Nephrology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Diabetic kidney disease (DKD) is a primary complication of diabetes mellitus (DM), leading to end-stage kidney disease (ESKD).
  • Current treatments for DKD are insufficient, with many patients progressing to ESKD.
  • The proximal tubule is critically involved in DKD progression.

Purpose of the Study:

  • To review current knowledge on proximal tubule cell-targeted therapy for DKD.
  • To identify optimal targeting strategies for DKD treatment.
  • To explore novel therapeutic approaches for DKD.

Main Methods:

  • Literature review of targeted drug delivery strategies for DKD.
  • Analysis of proximal tubule cell targeting mechanisms.
  • Screening of potential therapeutic agents and delivery systems.

Main Results:

  • Targeted drug delivery, including nanoparticles and prodrugs, enhances efficacy and reduces side effects in DKD treatment.
  • Proximal tubule targeting offers a promising strategy to combat DKD progression.
  • Various targeting strategies show potential for novel DKD therapies.

Conclusions:

  • Targeted drug delivery represents a significant advancement with broad application prospects for DKD treatment.
  • Focusing on proximal tubule cell-targeted therapy is crucial for developing effective new treatments for DKD.
  • Further research into optimal targeting strategies can lead to improved therapeutic outcomes for diabetic kidney disease patients.
Keywords:
diabetes mellitusdiabetic nephropathiesdrug delivery systemskidney tubulesmolecular targeted therapyproximal

More Related Videos

Direct Drug Delivery to Kidney via the Renal Artery11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

7.4K
Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models07:01

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

1.6K

Related Concept Videos

Drug Elimination by Renal Route: Tubular Secretion01:15

Drug Elimination by Renal Route: Tubular Secretion

Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
2.5K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
67
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
54
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
40
Renal Drug Excretion: Tubular Secretion01:28

Renal Drug Excretion: Tubular Secretion

Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
249