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Published on: June 20, 2018
Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy
Muyao Ye1, Ming Yang1, Wenni Dai1
1Department of Nephrology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha 410011, China.
Abstract:
As a metabolic disorder, obesity can cause secondary kidney damage, which is called obesity-related glomerulopathy (ORG). As the incidence of obesity increases worldwide, so does the incidence of end-stage renal disease (ESRD) caused by ORGs. However, there is still a lack of effective strategies to prevent and delay the occurrence and development of ORG. Therefore, a deeper understanding and elaboration of the pathogenesis of ORG is conducive to the development of therapeutic drugs for ORG. Here, we review the characteristics of pathological lesions of ORG and describe the roles of lipid metabolism disorders and mitochondrial oxidative stress in the development of ORG. Finally, we summarize the current available drugs or compounds for the treatment of ORG and suggested that ameliorating renal lipid metabolism and mitochondrial function may be potential therapeutic targets for ORG.
Insights
Obesity-related glomerulopathy (ORG) is a kidney disease linked to obesity. Targeting lipid metabolism and mitochondrial function may offer new treatments for ORG and prevent kidney failure.
Area of Science:
- Nephrology
- Metabolic Disorders
- Pathogenesis of Kidney Disease
Background:
- Obesity is a global metabolic disorder increasingly linked to kidney damage, termed obesity-related glomerulopathy (ORG).
- The rising incidence of obesity correlates with an increase in end-stage renal disease (ESRD) attributed to ORG.
- Current strategies for preventing and delaying ORG progression are limited, highlighting the need for a deeper understanding of its pathogenesis.
Purpose of the Study:
- To review the pathological characteristics of ORG.
- To elucidate the roles of disordered lipid metabolism and mitochondrial oxidative stress in ORG development.
- To summarize current therapeutic strategies and identify potential drug targets for ORG.
Main Methods:
- Literature review of pathological lesions in ORG.
- Analysis of the contribution of lipid metabolism dysregulation to ORG.
- Examination of the role of mitochondrial oxidative stress in ORG pathogenesis.
Main Results:
- ORG is characterized by specific pathological lesions.
- Disordered lipid metabolism significantly contributes to the development of ORG.
- Mitochondrial oxidative stress plays a crucial role in the progression of ORG.
Conclusions:
- Ameliorating renal lipid metabolism is a potential therapeutic strategy for ORG.
- Improving mitochondrial function may represent a novel therapeutic target for ORG.
- Further research into these pathways could lead to effective treatments for obesity-related kidney disease.
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