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Non-Apoptotic Programmed Cell Death in Thyroid Diseases

Feihong Ji1, Xinguang Qiu1

  • 1Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Pharmaceuticals (Basel, Switzerland)
|December 23, 2022
PubMed

Insights

Non-apoptotic programmed cell death (NAPCD) offers new therapeutic avenues for thyroid diseases. Understanding mechanisms like autophagy and pyroptosis in thyroid conditions can lead to better treatments.

Area of Science:

  • Endocrinology
  • Cell Biology
  • Pathophysiology

Background:

  • Thyroid disorders are common endocrinological conditions with increasing prevalence.
  • Non-apoptotic programmed cell death (NAPCD) presents potential in treating inflammatory and neoplastic diseases.
  • Classical NAPCD types include autophagy, pyroptosis, ferroptosis, and immunogenic cell death.

Purpose of the Study:

  • To review recent mechanistic investigations of thyroid diseases.
  • To establish the progress of NAPCD in thyroid disease research.
  • To elucidate the role of various NAPCD types in different thyroid disorders.

Main Methods:

  • Compilation of recent mechanistic investigations in thyroid diseases.
  • Review of literature on NAPCD roles in thyroid disorders.
  • Analysis of the impact of NAPCD on disease occurrence, progression, and prognosis.

Main Results:

  • NAPCD has demonstrated considerable progress in understanding and potentially treating thyroid diseases.
  • Specific roles of autophagy, pyroptosis, ferroptosis, and immunogenic cell death in various thyroid disorders have been elucidated.
  • NAPCD research provides insights into pathophysiology and potential new therapeutic targets.

Conclusions:

  • Understanding NAPCD mechanisms is crucial for advancing thyroid disease diagnosis and treatment.
  • NAPCD offers novel strategies for managing thyroid-related inflammatory and neoplastic conditions.
  • Future research in NAPCD holds promise for developing improved diagnostic and therapeutic approaches for thyroid diseases.
Keywords:
apoptosisautophagic cell deathferroptosisnon-apoptotic programmed cell deathpyroptosisthyroid disease

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