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Involvement of Bacterial Extracellular Membrane Nanovesicles in Infectious Diseases and Their Application in Medicine

Konstantin A Lusta1, Anastasia V Poznyak1, Larisa Litvinova2

  • 1Institute for Atherosclerosis Research, Osennyaya Street 4-1-207, 121609 Moscow, Russia.

Pharmaceutics
|December 23, 2022
PubMed

Insights

Bacterial extracellular membrane nanovesicles (EMNs) are key in disease development and immune response. These nanovesicles show promise as vaccine carriers and therapeutic agents for infections and cancer.

Area of Science:

  • Microbiology
  • Immunology
  • Nanotechnology

Background:

  • Bacterial extracellular membrane nanovesicles (EMNs) are increasingly recognized for their roles in disease pathogenesis.
  • EMNs are implicated in infectious diseases caused by Gram-positive and Gram-negative bacteria, as well as in cancer development.

Purpose of the Study:

  • To review the diverse roles of EMNs in various pathologies.
  • To explore the therapeutic and preventive potential of EMNs.

Main Methods:

  • Literature review focusing on EMNs in disease and therapy.
  • Analysis of EMNs' involvement in pathogenesis and immune stimulation.

Main Results:

  • EMNs play a significant role in the pathogenesis of numerous infectious diseases and cancers.
  • EMNs are effective carriers for vaccines against infectious diseases.
  • EMNs stimulate immune responses against bacterial pathogens and tumor cells.

Conclusions:

  • EMNs are crucial in understanding disease mechanisms and host-pathogen interactions.
  • EMNs offer significant potential for therapeutic applications, including vaccine development and treatment strategies for infections and cancer.
Keywords:
bacterial membraneexosomesinfectioninfectious diseasevesicles

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