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Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations
Sagar R Pardeshi1, Eknath B Kole2, Harshad S Kapare3
1Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, India.
Pharmaceutics
|December 23, 2022
Summary
Thin film freezing (TFF) is an advanced drying technology revolutionizing pharmaceutical and biopharmaceutical product commercialization. This technique offers promising therapeutic applications, particularly for lung diseases, through innovative drug delivery systems.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Food Science
Background:
- Surface drying is critical in pharmaceutical, biomedical, and food industries, yet presents formulation challenges.
- Emerging technologies are crucial for overcoming limitations in the final drying stage of product development.
Purpose of the Study:
- To review the fundamentals of Thin Film Freezing (TFF) and its modulated techniques.
- To highlight therapeutic applications of TFF in drug delivery, nanoformulations, dry powder inhalations, and vaccines.
Main Methods:
- Review of Thin Film Freezing (TFF) principles and advancements.
- Analysis of TFF applications in pharmaceutical and biopharmaceutical drying processes.
Main Results:
- TFF is a novel freeze-drying technique enabling commercialization across various industries.
- TFF demonstrates significant potential for developing advanced drug delivery systems, including inhalable powders and vaccines.
Conclusions:
- Thin Film Freezing (TFF) is a key technology for pharmaceutical and biopharmaceutical formulation and commercialization.
- TFF shows promise for treating lung diseases like fungal infections, bacterial infections, and pneumonia via targeted therapeutics.
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