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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Elderly sarcoidosis in Japan.

Nami Masumoto1, Keisuke Watanabe1, Nobuyuki Horita1

  • 1Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

The Journal of International Medical Research
|December 23, 2022
PubMed
Summary

Elderly Japanese patients with sarcoidosis often present with more comorbidities and extrathoracic muscle involvement compared to younger individuals. Further research is needed to understand how comorbidities impact the prognosis of geriatric sarcoidosis.

Keywords:
Agecomorbidityelderlyethnicityorgan involvementsarcoidosis

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Area of Science:

  • Pulmonology
  • Rheumatology
  • Geriatrics

Background:

  • Sarcoidosis manifestations vary geographically and ethnically.
  • Limited research exists on elderly sarcoidosis, primarily from Western countries.

Purpose of the Study:

  • To investigate the clinical characteristics of elderly sarcoidosis patients in Japan.
  • To compare elderly (≥65 years) and non-elderly (<65 years) sarcoidosis patients.

Main Methods:

  • Retrospective review of 106 pathologically confirmed sarcoidosis cases (April 2006 - March 2020).
  • Comparison of clinical features between elderly and non-elderly patient groups.

Main Results:

  • Elderly patients (33%) had more comorbidities (median 1 vs. 0).
  • Elderly patients showed higher rates of extrathoracic biopsy sites (57.1% vs. 33.8%).
  • Muscle lesions were more frequent in elderly patients at diagnosis (11.4% vs. 1.4%) and during follow-up (17.1% vs. 1.4%).

Conclusions:

  • Elderly sarcoidosis patients in Japan may experience increased muscle involvement and comorbidities.
  • Comorbidities could influence the prognosis of geriatric sarcoidosis, warranting further investigation.