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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Relatlimab and nivolumab in the treatment of melanoma

Lewis Au1, James Larkin2, Samra Turajlic3

  • 1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, VIC 3010, Australia; Cancer Dynamics Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

Cell
|December 23, 2022
PubMed

Insights

Combined immunotherapy using LAG-3 and PD-1 blockers shows promise for melanoma. Clinical trials evaluated relatlimab and nivolumab as a first-line treatment for advanced melanoma.

Area of Science:

  • Immunology
  • Oncology
  • Clinical Trials

Background:

  • Combined blockade of LAG-3 and PD-1 is a novel therapeutic strategy for melanoma.
  • Metastatic, resectable, high-risk, node-positive melanoma requires effective front-line treatments.

Purpose of the Study:

  • To evaluate the efficacy of combined relatlimab and nivolumab as a first-line treatment for metastatic, resectable, high-risk, node-positive melanoma.

Main Methods:

  • Two clinical trials were conducted.
  • Patients received front-line treatment with relatlimab and nivolumab.

Main Results:

  • The combination therapy demonstrated efficacy in treating advanced melanoma.
  • Specific results from Tawbi et al. and Amaria et al. were published in The New England Journal of Medicine and Nature, respectively.

Conclusions:

  • Combined LAG-3 and PD-1 blockade represents a significant advancement in melanoma treatment.
  • Relatlimab and nivolumab offer a new front-line option for patients with high-risk melanoma.

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