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Some observations of a correlation between the symmetry of large heavy-atom complexes and their binding sites on
R Ladenstein1, A Bacher, R Huber
1Max-Planck-Institut für Biochemie, Martinsried, F.R.G.
Journal of Molecular Biology
|June 5, 1987
Abstract:
Two large, electron dense heavy-metal complexes were found to bind to crystals of heavy riboflavin synthase. The crystallographic analysis by difference Fourier methods shows that the tungsten cluster compound [(W3O2(O2CCH3)6]2+, which has trigonal symmetry, binds to a site on the 3-fold axis of the protein. The heteropolytungstate compound [NaP5W30O110]14-, which has pentagonal symmetry, binds to a site on the 5-fold axis of the protein.