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Serum copeptin as a biomarker of hypertension in children with obesity

Zeynep Gor1, Digdem Bezen2, Yelda Turkmenoglu1

  • 1Department of Pediatrics, Health Science University, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|December 23, 2022
PubMed

Insights

Children with obesity and hypertension have higher levels of copeptin and uric acid, and lower potassium. These biomarkers may aid in diagnosing and monitoring pediatric hypertension.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Health in Children
  • Metabolic Disorders

Background:

  • Hypertension is increasingly prevalent in obese children.
  • The specific roles of copeptin and uric acid in pediatric obesity-related hypertension are not well understood.
  • This study investigates novel biomarkers for hypertension in this population.

Purpose of the Study:

  • To examine the relationship between hypertension and serum copeptin and uric acid levels in children with obesity.
  • To identify potential diagnostic and monitoring markers for pediatric hypertension.

Main Methods:

  • Study included 80 children with obesity admitted to a hospital.
  • Patients were categorized into hypertensive and non-hypertensive groups.
  • Serum copeptin levels were quantified using enzyme-linked immunosorbent assay.

Main Results:

  • Significantly elevated copeptin levels were observed in hypertensive children compared to non-hypertensive controls (p < 0.0001).
  • Hypertensive children also showed higher serum uric acid and lower serum potassium levels (p < 0.01).
  • A positive correlation was found between blood sodium and copeptin levels (p = 0.037).

Conclusions:

  • Obese children with hypertension exhibit higher serum copeptin and uric acid, and lower blood potassium.
  • Copeptin levels demonstrated a positive correlation with blood sodium levels.
  • Serum uric acid, potassium, and sodium, alongside copeptin, may be crucial for managing pediatric hypertension.
Abstract

Keywords:
childrencopeptinhypertensionobesityuric acid

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