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Interventional treatment of keratoacanthoderma: a case report.
Dan Mei1, Lei Song1, Jin-Qi Gao1
1Department of Interventional Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
The Journal of International Medical Research
|December 24, 2022
Summary
This case report details a keratoacanthoma on a patient with a history of leukemia. Despite successful chemoembolization, the patient succumbed to systemic organ failure due to multiple health issues.
Area of Science:
- Dermatology
- Oncology
Background:
- Keratoacanthoma is a common skin tumor.
- Immunosuppression is a risk factor for keratoacanthoma.
Observation:
- A 56-year-old male presented with a year-long growing lip mass.
- Pathology revealed epidermal changes, invasive squamous epithelium, and inflammation.
- Immunohistochemistry showed increased P16 and Ki-67.
Findings:
- The diagnosis was keratoacanthoma with malignancy and dysplasia.
- Initial surgical resection was followed by tumor recurrence.
- Intraoperative paclitaxel, cisplatin, and chemoembolization achieved remission.
Implications:
- This case highlights the aggressive nature of keratoacanthoma in immunosuppressed individuals.
- Multimodal therapy, including chemoembolization, can be effective.
- Patient comorbidities significantly impact prognosis.
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