Oesophageal Varices And Associated Factors In Cirrhotic Patients With Hepatitis C

Area of Science:

• Hepatology
• Gastroenterology
• Viral Hepatitis Research

Background:

• Hepatitis C virus (HCV) infection affects millions globally, often leading to liver cirrhosis.
• Liver cirrhosis significantly increases the risk of developing oesophageal varices, a serious complication.

Purpose of the Study:

• To determine the frequency of oesophageal varices in patients with HCV-related liver cirrhosis.
• To identify associated factors contributing to the development of oesophageal varices in this patient population.

Main Methods:

• A cross-sectional study was conducted in Karachi, Pakistan, involving 167 patients with HCV-related liver cirrhosis.
• Data collected included demographics, Child-Pugh scores, laboratory results (Hb, platelets, albumin, etc.), and presence of ascites and oesophageal varices.
• Statistical analysis was performed using SPSS to identify significant associations.

Main Results:

• Oesophageal varices were present in a high proportion (84.4%) of the 167 patients studied.
• Thrombocytopenia (77.8%) and ascites were common findings.
• A significant association was found between oesophageal varices and thrombocytopenia (p<0.001), ascites (p=0.024), and Child-Pugh class C (p=0.012).

Conclusions:

• Oesophageal varices are a frequent complication in patients with HCV-related liver cirrhosis.
• Thrombocytopenia, ascites, and advanced Child-Pugh class C are significant contributing factors to the presence of oesophageal varices.