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Diabetic cardiomyopathy: Clinical phenotype and practice

Xudong Zhao1,2, Shengwang Liu3,2, Xiao Wang3,2

  • 1Department of Endocrine and Metabolic Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Xiqing, Tianjin, China.

Frontiers in Endocrinology
|December 26, 2022
PubMed

Insights

Diabetic cardiomyopathy (DCM) involves heart changes in diabetes patients, increasing heart failure risk. This review examines DCM

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Diabetic cardiomyopathy (DCM) is a cardiac condition in diabetic individuals.
  • It occurs independently of coronary artery disease and hypertension.
  • DCM significantly elevates the risk of heart failure, yet effective treatments are limited.

Purpose of the Study:

  • To review the literature on diabetic cardiomyopathy over the past 40 years.
  • To provide an updated perspective on DCM's complex phenotype and progression.
  • To explore potential clinical indicators, diagnostic criteria, and existing clinical trials for DCM.

Main Methods:

  • Comprehensive literature search on diabetic cardiomyopathy.
  • Analysis of studies published over the last four decades.
  • Synthesis of findings regarding DCM's characteristics, progression, and management.

Main Results:

  • The complex phenotype of DCM remains incompletely understood despite extensive research.
  • Understanding DCM is crucial for advancing clinical and basic research.
  • A comprehensive overview of DCM's progression, indicators, and trials is presented.

Conclusions:

  • Diabetic cardiomyopathy presents a significant clinical challenge with poor prognosis.
  • Further research is needed to fully elucidate DCM's mechanisms and improve patient outcomes.
  • This review aims to consolidate current knowledge and guide future investigations into DCM.

Keywords:
diabetic cardiomyopathydiagnosisphase of progressionreviewscreeningtreatment

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