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Related Experiment Video

Updated: Aug 16, 2025

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine.

Helen Steins^1,2, Michael Mierzejewski¹, Lisa Brauns¹

¹NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.

Microsystems & Nanoengineering

|December 26, 2022

Summary

Researchers developed a novel 3D microelectrode array for precise neural signal recording. This low-invasive device offers improved signal quality for studying autonomic nerves and advancing bioelectronic medicine applications.

Keywords:

Engineering Materials science

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Last Updated: Aug 16, 2025

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

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Published on: September 27, 2013

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

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Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

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Published on: February 12, 2020

Area of Science:

Bioelectronic Medicine
Neural Engineering
Microsystems Technology

Background:

Recording neural signals from delicate autonomic nerves is difficult.
Existing neural interfaces lack the required selectivity and micrometer-sized electrodes.

Purpose of the Study:

To develop a low-invasive, three-dimensional (3D) protruding thin-film microelectrode array (MEA).
To enable selective recording of low-amplitude neural signals from autonomic nervous structures.

Main Methods:

Fabrication of cylindrical gold pillars on a polyimide substrate using electroplating.
Insulation of sidewalls with parylene C and optional tip modification (wet etching, TiN coating).
Evaluation of microelectrode impedance and noise levels, followed by ex vivo testing with mouse retinae.

Main Results:

Developed 3D microelectrodes with low impedances (~7 kΩ) and low intrinsic noise.
Successfully recorded spontaneous neuronal spikes with amplitudes up to 66 µV in mouse retinae.
Demonstrated the potential for transverse nerve penetration to reduce recording distance.

Conclusions:

The novel process enables fabrication of flexible, 3D neural interfaces with low-impedance microelectrodes.
This technology can selectively record neural signals from delicate structures like retinal cells and autonomic nerves.
Offers potential for improved signal quality in bioelectronic medicine for neural circuit studies and stimulation strategies.