Related Experiment Video
Updated: Aug 16, 2025
06:46
Author Spotlight: Enhanced Urodynamic Method for Precise Urine Measurement in Awake Mice with Neurogenic Bladder
Published on: June 7, 2024
793
A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder
Qi Li1,2, Miao Cai1,2, Qingsong Pu3
1Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Pediatrics
|December 26, 2022
Summary
A new predictive model helps identify children with neurogenic bladder (NB) at risk for upper urinary tract damage (UUTD). This tool aids in early assessment and management of NB complications.
Area of Science:
- Pediatric Urology
- Nephrology
- Medical Informatics
Background:
- Neurogenic bladder (NB) in children can lead to serious upper urinary tract damage (UUTD).
- Predictive tools are needed to identify children at high risk for UUTD progression.
Purpose of the Study:
- To develop and validate a predictive model (nomogram) for upper urinary tract damage (UUTD) in pediatric patients with neurogenic bladder (NB).
Main Methods:
- Retrospective study with training (167 patients) and validation (100 patients) cohorts.
- Logistic regression analysis identified predictors: recurrent UTIs, bladder compliance, detrusor leak point pressure, overactive bladder, and clean intermittent catheterization.
- Model efficacy assessed using ROC curves, calibration plots, and decision curve analysis.
Main Results:
- The nomogram demonstrated good predictive accuracy (AUC 0.806 in training, 0.831 in validation).
- Calibration curves confirmed good agreement between predicted and observed UUTD risk.
- Decision curve analysis supported the nomogram's clinical utility.
Conclusions:
- An effective nomogram incorporating five clinical factors was developed to assess UUTD risk in children with NB.
- This tool can be conveniently applied for early risk stratification and management of NB patients.
Related Concept Videos
01:19Urodynamic Studies: Uroflowmetry
278
Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
278
01:21Nursing Assessment of the Genitourinary System I: Health History
64
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
64
01:28Urinary Tract Calculi V: Nursing Management
20
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
20
01:26Nursing Assessment of the Genitourinary System II: Inspection and Palpation
189
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
189
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
27
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
27
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
170
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
170