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Anti-immunoglobulin-like transcript 3 induced acute myocarditis-A case report
Osnat Itzhaki Ben Zadok1,2, Arthur Shiyovich1,2, Ashraf Hamdan1,2
1Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel.
Frontiers in Cardiovascular Medicine
|December 26, 2022
Summary
This is the first report of myocarditis caused by anti-immunoglobulin-like transcript 3 (ILT3) therapy. Prompt steroid treatment led to rapid recovery in a patient with acute myeloid leukemia.
Area of Science:
- Immunology
- Cardiology
- Oncology
Background:
- Acute myeloid leukemia (AML) is a hematologic malignancy.
- Immunoglobulin-like transcript 3 (ILT3) is a target for cancer immunotherapy.
- Myocarditis is inflammation of the heart muscle.
Observation:
- A patient with refractory AML received anti-ILT3 monotherapy.
- The patient developed symptoms of myocarditis, including fever, hypotension, and chest pain.
- Cardiac biomarkers were elevated, but biventricular function remained normal.
Findings:
- Cardiac magnetic resonance imaging confirmed acute myocarditis.
- The patient responded well to pulse dose steroids, showing clinical and biomarker improvement.
- This is the first reported case of anti-ILT3-induced myocarditis.
Implications:
- Anti-ILT3 therapy may induce myocarditis as a non-target adverse effect.
- A high index of suspicion for cardiac complications is necessary in patients receiving anti-ILT3 drugs.
- Further research is needed to determine the incidence, management, and prognosis of this condition.
