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Updated: Aug 16, 2025
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
COVID Associated Invasive Aspergillosis.
Sudhir Bhandari1, Shubhangi Gupta2, Shruti Bhargava3
1Jaipur, India Department of Medicine, SMS Medical College.
A study found a strong link between invasive fungal sinusitis (aspergillosis) and coronavirus disease (COVID-19). Uncontrolled diabetes and steroid use during COVID-19 treatment were key aggravating factors.
Area of Science:
- Otolaryngology
- Infectious Diseases
- Mycology
Background:
- Invasive fungal sinusitis, particularly aspergillosis, is an emerging concern.
- The association between coronavirus disease (COVID-19) and secondary fungal infections requires investigation.
Purpose of the Study:
- To investigate the association between invasive fungal sinusitis (aspergillosis) and COVID-19.
Main Methods:
- An observational study was conducted over six months at a tertiary care center.
- Included patients with paranasal sinus aspergillosis and a history of or active COVID-19 infection.
Main Results:
- All 92 patients studied had aspergillosis associated with COVID-19.
- The maxillary sinus was most commonly affected (100%).
- Orbital and intracranial extensions occurred in 34 and 5 cases, respectively. Diabetes mellitus (75/92) and prior steroid use for COVID-19 were prevalent.
Conclusions:
- A significant association exists between COVID-19 and invasive fungal sinusitis (aspergillosis).
- Uncontrolled diabetes and excessive steroid use are critical factors exacerbating this condition.
- These factors necessitate careful management in patients with COVID-19 and suspected fungal sinusitis.
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