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Related Experiment Video

Updated: Aug 16, 2025

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Treating Chronic Pain with Deep Brain Stimulation.

Hao Tan¹, Erin A Yamamoto¹, Mohammed A Elkholy²

¹Department of Neurological Surgery, Oregon Health and Science University, Mail Code CH8N, 3303 South Bond Avenue, Portland, OR, 97239, USA.

Current Pain and Headache Reports

|December 26, 2022

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) shows promise for chronic pain management, though high-evidence data is still needed. Ongoing trials explore advanced techniques to refine DBS for better patient outcomes in pain treatment.

Keywords:

Chronic pain DBS Deep brain stimulation Neuromodulation

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Area of Science:

Neurology
Neurosurgery
Pain Management

Background:

Deep brain stimulation (DBS) for chronic pain has faced historical controversy.
Despite past challenges, there is ongoing interest in optimizing DBS for improved patient outcomes.

Purpose of the Study:

To provide a concise overview of DBS for chronic pain.
To serve as a reference for clinicians regarding DBS in pain management.

Main Methods:

Review of recent data and ongoing clinical trials.
Exploration of novel approaches like closed-loop neuromodulation and invasive EEG monitoring.

Main Results:

Emerging data tentatively supports DBS for chronic pain, but high-level evidence is lacking.
Several clinical trials are investigating refined DBS techniques, targets, and parameters.

Conclusions:

Deep brain stimulation (DBS) is a potentially viable treatment for chronic pain.
Successful outcomes depend on careful patient selection and target identification.
Future trial results will guide the refinement of DBS for pain indications.