Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

5.4K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.4K
Brain Imaging01:14

Brain Imaging

278
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
278

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Brain charts for the human lifespan.

Nature·2022
Same author

Brain charts for the human lifespan.

Nature·2022
Same author

Influence of BDNF Val66Met polymorphism on excitatory-inhibitory balance and plasticity in human motor cortex.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021
Same author

Impact of emotionally-charged images and trial order on downstream cognitive processing: An ERP study.

Neuropsychologia·2021
Same author

The administration of the opioid buprenorphine decreases motivational error signals.

Psychoneuroendocrinology·2021
Same author

Interplay of self-other distinction and cognitive control mechanisms in a social automatic imitation task: An ERP study.

Cognitive, affective & behavioral neuroscience·2021

Related Experiment Video

Updated: Aug 16, 2025

Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging
10:09

Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging

Published on: September 12, 2012

13.9K

Acute TMS/fMRI response explains offline TMS network effects - An interleaved TMS-fMRI study.

M Tik1, M Woletz1, A-L Schuler1

  • 1High-Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.

Neuroimage
|December 26, 2022
PubMed
Summary
This summary is machine-generated.

Transcranial magnetic stimulation (TMS) targeting the dorsolateral prefrontal cortex (DLPFC) activates specific brain networks, including the anterior cingulate cortex (ACC). This clarifies TMS mechanisms for treating depression and related disorders.

Keywords:
1000 functional connectomes projectACCAcute TMS effectsClinical applicationTMS/fMRI

More Related Videos

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

13.0K
Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course
11:33

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Published on: July 18, 2014

43.1K

Related Experiment Videos

Last Updated: Aug 16, 2025

Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging
10:09

Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging

Published on: September 12, 2012

13.9K
Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

13.0K
Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course
11:33

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Published on: July 18, 2014

43.1K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Transcranial magnetic stimulation (TMS) is an FDA-approved treatment for depression, but its precise mechanisms and network effects remain unclear.
  • Understanding how TMS, particularly DLPFC stimulation, affects brain networks is crucial for optimizing its efficacy.
  • Existing evidence on DLPFC stimulation's indirect modulation of the subgenual anterior cingulate cortex (sgACC) is limited.

Purpose of the Study:

  • To delineate the specific brain networks and downstream regions activated by DLPFC-TMS.
  • To investigate the acute network effects of TMS using concurrent interleaved TMS/fMRI.
  • To establish a causal link between DLPFC-TMS and brain network activation.

Main Methods:

  • Concurrent interleaved TMS/fMRI was employed with specialized MRI head coils.
  • Analysis focused on delineating networks and downstream regions activated by DLPFC-TMS.
  • Resting-state brain networks were compared with acute BOLD signal changes during TMS.

Main Results:

  • Acute BOLD signal activation during TMS showed topographical overlap with a previously identified resting-state network (RSN#17).
  • This overlap occurred across widespread cortical and sub-cortical areas, including the ACC.
  • The findings suggest a direct relationship between TMS-induced BOLD activity and network connectivity.

Conclusions:

  • DLPFC-TMS causally relates to ACC activation and a broader network implicated in Major Depressive Disorder (MDD).
  • These findings advance the understanding of TMS's mechanistic targets.
  • This research may offer new ways to characterize and optimize TMS therapy for various neurological and psychiatric conditions.