Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

842
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
842
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

115
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
115

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does a monoclonal antibody targeting immune cells affect glutamatergic level in schizophrenia? A multimodal PET/MRS brain imaging study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Test-Retest Reliability of Sensorimotor Activity Measured With Spinal Cord fMRI.

Human brain mapping·2026
Same author

A 3D-printed phantom to validate subject orientation in 3D imaging and recordings.

Frontiers in neuroinformatics·2026
Same author

Correction to: Ultra-low-field brain MRI morphometry: Test-retest reliability and correspondence to high-field MRI.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

EXPRESS: Quantitative functional BOLD (qfBOLD): A Combined Gradient-Echo and Spin-Echo Framework for Oxygen Extraction Fraction (OEF) Mapping with functional MRI.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Multiparametric MRI and imaging transcriptomics reveal molecular and cellular correlates of neurodegeneration in experimental Parkinsonism.

NPJ Parkinson's disease·2026

Related Experiment Video

Updated: Aug 16, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.8K

Erbb4 Deletion From Inhibitory Interneurons Causes Psychosis-Relevant Neuroimaging Phenotypes.

Amanda Kiemes1, Maria Elisa Serrano Navacerrada2, Eugene Kim2

  • 1Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.

Schizophrenia Bulletin
|December 27, 2022
PubMed
Summary

Disrupting inhibitory interneurons in mice mimics psychosis neuroimaging findings. This study links interneuron deficits to cerebral blood flow and synaptic density changes, offering cross-species biomarkers for psychosis research.

Keywords:
Erbb4hippocampusinhibitory interneuronsmiceneuroimagingpsychosis

More Related Videos

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

13.0K
Developing a Rat Model for Bipolar Disorder
04:44

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

418

Related Experiment Videos

Last Updated: Aug 16, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.8K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

13.0K
Developing a Rat Model for Bipolar Disorder
04:44

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

418

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Dysfunction of cortical GABAergic inhibitory interneurons is implicated in psychosis.
  • Neuroimaging abnormalities in psychosis, like altered cerebral blood flow (CBF) and metabolite levels, are linked to the hippocampus.
  • Schizophrenia susceptibility gene Erbb4 disruption in interneurons causes psychosis-relevant phenotypes in mice.

Purpose of the Study:

  • To investigate the impact of inhibitory interneuron disruption on hippocampal in vivo neuroimaging readouts.
  • To establish direct links between inhibitory interneuron dysfunction and neuroimaging markers in psychosis.
  • To determine if Erbb4 gene deletion in interneurons affects CBF, metabolite levels, and receptor/transporter densities.

Main Methods:

  • Used conditional mutant mice with Erbb4 deleted in cortical and hippocampal inhibitory interneurons.
  • Quantified in vivo hippocampal cerebral blood flow (CBF) and glutamatergic metabolite levels (glutamine, glutamate, GABA) using 9.4T magnetic resonance scanning.
  • Assessed GABAA receptor and synaptic vesicle glycoprotein 2A (SV2A) density via quantitative autoradiography.

Main Results:

  • Erbb4 mutant mice exhibited elevated ventral hippocampus CBF and glutamine levels.
  • A significant decrease in SV2A density was observed across hippocampal sub-regions in mutant mice.
  • No significant differences in GABAA receptor density were found between mutant and wild-type mice.

Conclusions:

  • Disruption of cortical inhibitory interneurons in mice replicates key neuroimaging findings seen in human psychosis.
  • This study establishes a link between inhibitory interneuron deficits and non-invasive brain function/neurochemistry measures.
  • The findings provide cross-species applicable biomarkers for psychosis research.