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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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Clinical Issues-January 2023.

Emily Jones

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    Summary
    This summary is machine-generated.

    Janus kinase (JAK) inhibitor therapy may increase venous thromboembolism risk in inflammatory bowel disease patients. Validated risk assessment tools are crucial for identifying and managing this risk, especially in surgical settings.

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    Area of Science:

    • Pharmacology and Gastroenterology
    • Clinical Risk Management

    Background:

    • Janus kinase (JAK) inhibitors, such as tofacitinib, are used for inflammatory bowel disease (IBD), including ulcerative colitis.
    • JAK inhibitor therapy has been associated with an increased risk of venous thromboembolism (VTE).
    • Effective VTE risk assessment and prophylaxis are critical in managing patients with IBD, particularly those undergoing surgery.

    Purpose of the Study:

    • To review the association between Janus kinase (JAK) inhibitor therapy and venous thromboembolism (VTE) risk factors in patients with inflammatory bowel disease (IBD).
    • To evaluate the utility of validated venous thromboembolism risk assessment tools, such as the Caprini risk assessment model (RAM).
    • To examine the optimal timing and communication strategies for VTE risk assessment and management in the perioperative setting.

    Main Methods:

    • Literature review and synthesis of evidence regarding JAK inhibitor therapy and VTE risk.
    • Analysis of the application and validation of risk assessment models like the Caprini RAM in clinical workflows.
    • Examination of protocols for preoperative VTE risk assessment and postoperative risk communication.

    Main Results:

    • Janus kinase (JAK) inhibitors are linked to increased venous thromboembolism (VTE) risk in patients with inflammatory bowel disease (IBD).
    • The Caprini risk assessment model (RAM) is a validated tool for identifying VTE risk, aiding clinical workflow and patient assessment.
    • Effective communication of VTE and bleeding risks during patient handovers is essential for safe postoperative care.

    Conclusions:

    • Extended-duration prophylaxis may be considered for inflammatory bowel disease (IBD) patients on Janus kinase (JAK) inhibitors.
    • Integrating validated venous thromboembolism (VTE) risk assessment tools into clinical practice improves risk identification and management.
    • Standardized preoperative assessment and clear communication of risks are vital for optimizing patient safety and outcomes.