Apolipoprotein E (APOE) Genotypes in the Israeli population
Gideon Charach1, Lior Charach1, Eli Karniel1
1Department of Internal Medicine B, Meir Medical Center, Kfar Saba, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
The Israel Medical Association Journal : IMAJ
|December 27, 2022
Summary
This study determined Apolipoprotein E (APOE) genotype frequencies in Israeli newborns. APOE genotype 3/3 was most common, with variations observed based on parental origin, highlighting genetic diversity in cardiovascular risk factors.
Area of Science:
- Genetics
- Cardiovascular Disease Epidemiology
- Neonatal Health
Background:
- Apolipoprotein E (APOE) genotype significantly influences plasma lipid levels and the risk of cardiovascular disease and cognitive decline.
- Ethnic variations in APOE genotype frequencies are known to impact cardiovascular morbidity and cognitive deterioration.
Purpose of the Study:
- To evaluate the apo-e allelic frequency among Israeli newborns.
- To investigate potential ethnic variations in APOE genotype distribution within the Israeli population.
Main Methods:
- Analysis of 498 consecutive neonates at Tel Aviv Sourasky Medical Center.
- Umbilical cord blood sampling for APOE genotyping and lipid profiling.
- Collection of demographic data and parental risk factors for atherosclerosis.
Main Results:
- The prevalence of APOE genotypes in Israeli newborns was determined: APOE 2/2 (1.4%), APOE 2/3 (8.2%), APOE 3/3 (77.7%), and APOE 4/4 (11.8%).
- No significant associations were found between APOE genotype and parental country of origin.
- A trend suggested APOE 3/4 was more frequent in newborns of Asian and African parentage, while APOE 3/3 was more common in those with European/American roots.
Conclusions:
- Determining APOE genotype is crucial for evaluating premature atherosclerosis risk.
- Identifying genetic and environmental risk factors can aid in earlier treatment and prevention of atherosclerosis.
- APOE genotypes did not demonstrate an effect on newborn lipid profiles (total cholesterol, LDL, HDL, triglycerides).
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