Related Experiment Video
Updated: Aug 16, 2025
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Assessment of MRF for simultaneous T1 and T2 quantification and water-fat separation in the liver at 0.55 T
Yuchi Liu1, Jesse Hamilton2,3, Yun Jiang2,3
1Department of Radiology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI, 48109, USA. yuchiliu@med.umich.edu.
Objective:
The goal of this work was to assess the feasibility of performing MRF in the liver on a 0.55 T scanner and to examine the feasibility of water-fat separation using rosette MRF at 0.55 T.
Materials And Methods:
Spiral and rosette MRF sequences were implemented on a commercial 0.55 T scanner. The accuracy of both sequences in T1 and T2 quantification was validated in the ISMRM/NIST system phantom. The efficacy of rosette MRF in water-fat separation was evaluated in simulations and water/oil phantoms. Both spiral and rosette MRF were performed in the liver of healthy subjects.
Results:
In the ISMRM/NIST phantom, both spiral and rosette MRF achieved good agreement with reference values in T1 and T2 measurements. In addition, rosette MRF enables water-fat separation and can generate water- and fat- specific T1 maps, T2 maps, and proton density images from the same dataset for a spatial resolution of 1.56 × 1.56 × 5mm3 within the acquisition time of 15 s.
Conclusion:
It is feasible to measure T1 and T2 simultaneously in the liver using MRF on a 0.55 T system with lower performance gradients compared to state-of-the-art 1.5 T and 3 T systems within an acquisition time of 15 s. In addition, rosette MRF enables water-fat separation along with T1 and T2 quantification with no time penalty.
