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Serum Long Noncoding RNA H19 and CKD Progression in IgA Nephropathy
Lijie He1, Hanmin Wang2, Peng He1
1Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Journal of Nephrology
|December 27, 2022
Summary
Serum H19 levels are downregulated in IgA nephropathy (IgAN) patients. Higher H19 expression is linked to a better prognosis and reduced kidney disease progression in IgAN patients.
Area of Science:
- Nephrology
- Molecular Biology
- Genetics
Background:
- IgA nephropathy (IgAN) is a prevalent glomerular disease, particularly in young Asian adults.
- Long non-coding RNA H19 is implicated in renal pathologies, but its role in IgAN progression was unclear.
Purpose of the Study:
- To investigate the association between serum H19 expression and kidney disease progression in IgAN patients.
- To determine if H19 serves as a prognostic biomarker for IgAN.
Main Methods:
- Serum H19 levels were measured in 204 IgAN patients using RT-qPCR.
- Statistical analyses included log-transformation, ROC curve analysis, restricted cubic splines, and generalized estimating equations.
- Covariates included clinical, pathological, and treatment factors.
Main Results:
- Serum H19 was significantly downregulated in IgAN patients compared to controls.
- H19 expression showed a negative linear correlation with disease progression.
- Elevated H19 levels (H19 > 0.097) were associated with a 70% reduced risk of kidney progression within 5 years (HR, 0.30).
- H19 demonstrated significant prognostic value (AUC = 0.746).
Conclusions:
- Serum H19 is an independent protective factor in IgA nephropathy.
- High serum H19 levels indicate a better renal outcome within a 5-year period.
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