[Method of radionuclide determination of coronary blood flow: experimental verification and clinical testing]

For quantitative assessment of the coronary blood flow in diagnostic examination of CHD patients the authors have proposed a new method for determination of absolute values of the coronary blood flow by intragastric administration of 99m Tc-labeled human serum albumin microspheres with subsequent whole body scintigraphy and comparison of scintillation count intensity over the heart area and the whole body. The results of experiments on 13 rabbits for verification of the method and the results of clinical testing in 20 patients were presented. The proposed method was shown to ensure adequate assessment of the coronary blood flow in ml/min. the patient's safety without interfering in routine coronary angiographic investigation, providing very important additional diagnostic information. The method was recommended for clinical diagnostic practice in x-ray departments of cardiological hospitals.