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The Quantification of Injectability by Mechanical Testing
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Recombinant protein-based injectable materials for biomedical applications.

Cristobal Garcia Garcia1, Sai S Patkar1, Bin Wang1

  • 1Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.

Advanced Drug Delivery Reviews
|December 27, 2022
PubMed
Summary

Recombinant protein-based materials offer customizable injectable platforms for drug delivery and tissue engineering. These advanced biomaterials provide tunable properties and stimuli-responsive features for enhanced biomedical applications.

Keywords:
Bioinspired materialsDrug deliveryInjectable hydrogelsNanocarriersPolypeptidesRecombinant proteinsRegenerative medicineStimuli-responsive polymersTissue engineering

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Tissue Engineering

Background:

  • Injectable nanocarriers and hydrogels are crucial for biotherapeutic delivery and tissue engineering.
  • Recombinant protein-based materials are emerging as versatile platforms for these applications.

Purpose of the Study:

  • To review recent advances in recombinant protein-based injectable materials.
  • To highlight their applications in nanocarrier and tissue engineering matrix development.

Main Methods:

  • Review of current literature on protein-engineered biomaterials.
  • Analysis of stimuli-responsive properties and their advantages.

Main Results:

  • Protein-engineered biomaterials offer high customizability.
  • Tunable rheological properties, encapsulation efficiencies, and delivery profiles are key advantages.
  • Stimuli-responsive properties of these materials enable advanced functionalities.

Conclusions:

  • Recombinant protein-based materials represent a significant advancement in injectable platforms.
  • Their customizable and stimuli-responsive nature makes them ideal for sophisticated biomedical applications.