Cannabidiol and Δ8-Tetrahydrocannabinol: Cannabinoids of Rising Interest and Concern

Area of Science:

• Cannabinoid Science
• Pharmacology
• Molecular Biology

Background:

• Delta-9 tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are well-researched cannabinoids.
• Delta-8 tetrahydrocannabinol (Δ8-THC), a double-bond isomer of Δ9-THC, has received less scientific attention.
• The 2018 US Farm Bill legalized hemp cultivation, increasing interest in hemp-derived compounds like Δ8-THC and CBD.

Purpose of the Study:

• To review and summarize the current scientific understanding of Δ8-THC.
• To consolidate knowledge on the pharmacodynamics and pharmacokinetics of CBD.
• To explore emerging topics including plant genetics, cannabinoid effects on viral entry, and consumption methods.

Main Methods:

• Literature review and synthesis of existing research on Δ8-THC and CBD.
• Analysis of studies on cannabinoid metabolism and effects.
• Examination of research on viral entry mechanisms and cannabinoid interactions.

Main Results:

• Limited data exists on Δ8-THC's effects, metabolism, and pharmacodynamics compared to Δ9-THC and CBD.
• CBD's pharmacodynamics and pharmacokinetics are better understood, with ongoing research into its therapeutic potential.
• Cannabinoids may influence viral entry into mammalian cells, warranting further investigation.

Conclusions:

• Further research is crucial to elucidate the effects, safety, and therapeutic potential of Δ8-THC.
• Understanding cannabinoid interactions with cellular processes, like viral entry, is an important area for future study.
• Comprehensive knowledge of hemp-derived cannabinoids is needed, especially concerning evolving consumption practices.