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Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
Florian Tran1,2, Danielle M M Harris1,3, Alena Scharmacher1
1Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
ERJ Open Research
|December 28, 2022
Abstract:
In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv.
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