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Two new ester alkaloids from Portulaca oleracea L. and their bioactivities
Jiayin Tian1, Mingbo Zhang1, Yingdai Zhao1
1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, P.R. China.
Abstract:
Two new ester alkaloids were isolated from Portulaca oleracea L., identified as (5-aminofuran-2-yl) methyl acetate (1) named oleracone N and 4(S)-ethyl 3-acetamido-3-(dihydroxyamino) propanoate (2) named oleracone O. The structures were elucidated via spectroscopic methods, including 1 D and 2 D NMR, UHPLC-ESI-QTOF/MS and CD spectrometry technique. It was suggested that both oleracone N and oleracone O could significantly inhibit inflammatory factors IL-1β and TNF-α in RAW 264.7 cells induced by LPS.
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