Characteristics of medicine use for children with asthma in China: a nationwide population-based study

Ping Wu1,2, Baoping Xu2, Adong Shen2

  • 1Department of Allergy, Immunology and Rheumatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, No. 318 Renmin Middle Road, Yuexiu District, Guangzhou, 510120, Guangdong, China.

BMC Pediatrics
|December 28, 2022
PubMed

Insights

Asthma medication use in Chinese children shows lower use of inhaled corticosteroids (ICS) and short-acting beta-agonists but higher use of oral corticosteroids and theophylline compared to Western countries. Further guideline popularization is needed.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacoeconomics
  • Public Health

Background:

  • Asthma is a significant respiratory condition in children.
  • Understanding medication patterns is crucial for effective asthma management.
  • Chinese asthma treatment guidelines and international recommendations (GINA) guide therapeutic approaches.

Purpose of the Study:

  • To analyze asthma medication utilization in Chinese children.
  • To compare medication patterns across different age groups, regions, and city levels in China.
  • To assess adherence to established asthma treatment guidelines.

Main Methods:

  • A cross-sectional study design was used.
  • Data were extracted from the 2015 China Healthcare Insurance Research Association (CHIRA) database.
  • Children aged 0-14 years diagnosed with asthma (ICD-10 codes J45, J46) were included.

Main Results:

  • 2,468 children with asthma were analyzed from a larger cohort of 308,550 children.
  • Compared to European/American countries, Chinese children used less inhaled corticosteroids (ICS) and short-acting beta-agonists.
  • Higher utilization of oral corticosteroids, long-acting beta-agonists, and theophylline (especially IV) was observed, particularly in Central and West China.

Conclusions:

  • Asthma medication use in Chinese children differs significantly from Western patterns.
  • There is a need to promote adherence to GINA and China's asthma guidelines, especially in less developed regions.
  • Targeted interventions are required to optimize asthma pharmacotherapy in China.
Abstract

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