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Atypical parathyroid adenoma: A case report.
Chayma Besrour1,2, Imen Rojbi1,2, Nadia Mchirgui1,2
1Department of Endocrinology Charles Nicolle Hospital Tunis Tunisia.
Clinical Case Reports
|December 29, 2022
Summary
A rare atypical parathyroid adenoma caused severe hypercalcemia and high parathormone (PTH) levels. Surgical removal normalized PTH, highlighting the need for careful diagnosis and surveillance of these tumors.
Area of Science:
- Endocrinology
- Surgical Pathology
Background:
- Atypical parathyroid adenoma is a rare tumor with uncertain malignant potential, posing diagnostic challenges.
- Primary hyperparathyroidism can manifest with severe hypercalcemia and significantly elevated parathormone (PTH) levels.
Observation:
- A 55-year-old woman presented with severe hypercalcemia and markedly elevated PTH (1325.62 pg/ml) due to a large left inferior parathyroid adenoma.
- Histopathological examination of the resected tumor confirmed it as an atypical parathyroid adenoma.
Findings:
- Surgical resection of the atypical parathyroid adenoma led to a significant decrease in postoperative PTH levels to 152 pg/ml.
- The case underscores the diagnostic difficulties and the need for vigilant monitoring in atypical parathyroid adenoma.
Implications:
- Accurate histological diagnosis and prompt surgical intervention are crucial for managing atypical parathyroid adenomas.
- Long-term patient surveillance is essential due to the uncertain malignant potential and incompletely understood outcomes of atypical parathyroid adenomas.
