Related Experiment Video
Updated: Aug 15, 2025

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
Shaping the host cell environment with viral noncoding RNAs
Carlos Gorbea1, Abdalla Elhakiem1, Demián Cazalla1
1Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Abstract:
Just like the cells they infect viruses express different classes of noncoding RNAs (ncRNAs). Viral ncRNAs come in all shapes and forms, and they usually associate with cellular proteins that are important for their functions. Viral ncRNAs have diverse functions, but they all contribute to the viral control of the cellular environment. Viruses utilize ncRNAs to regulate viral replication, to decide whether they should remain latent or reactivate, to evade the host immune responses, or to promote cellular transformation. In this review we describe the diverse functions played by different classes of ncRNAs expressed by adenoviruses and herpesviruses, how they contribute to the viral infection, and how their study led to insights into RNA-based mechanisms at play in host cells.
Related Concept Videos
Viruses with RNA Genomes
Types of RNA
RNA Performs Diverse...
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
Size and Structure of Viral Genomes
Retrovirus Life Cycles
Retroviruses

