Application of SERS in In-Vitro Biomedical Detection

Area of Science:

• Biomedical Diagnostics
• Analytical Chemistry
• Spectroscopy

Background:

• Surface-enhanced Raman scattering (SERS) is a powerful technique for rapid, non-destructive biological sample analysis.
• On-spot detection of biomedical samples presents significant challenges in clinical settings.
• SERS shows great promise for early diagnosis and point-of-care applications.

Purpose of the Study:

• To summarize recent developments in SERS for biomedical detection.
• To highlight SERS applications in various clinical diagnostics.
• To discuss strategies for enhancing SERS performance in biomedical contexts.

Main Methods:

• Review of SERS substrate engineering (structural and component).
• Analysis of SERS detection strategies for biomolecules (nucleic acids, proteins) and pathogens (bacteria, viruses).
• Exploration of SERS combined with other analytical techniques.

Main Results:

• SERS substrates and detection strategies have been significantly advanced.
• Promising applications demonstrated in cancer detection, infectious disease screening, and neurological disorder diagnosis.
• Integration of SERS with other analytical methods enhances detection capabilities.

Conclusions:

• SERS is a rapidly evolving field with substantial potential for clinical diagnostics.
• Ongoing research addresses challenges in substrate design and data processing for improved SERS performance.
• Future perspectives include broader clinical adoption and integration into point-of-care testing.