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Bioresorbable Electrically-Active Neuromodulation Materials & Devices.

Jiajun Cheng1, Huiyan Li1, Yao Chen1

  • 1Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources, Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing, China.

Chemistry, an Asian Journal
|January 18, 2026
PubMed
Summary
This summary is machine-generated.

Bioresorbable electrically-active neuromodulation devices (BEANDs) offer a new approach to treating neurological disorders by dissolving after use, eliminating removal surgery. This review covers their materials, device modules, and energy management for personalized therapy.

Keywords:
active neuromodulationbioresorbable materialsclinical translationelectrical stimulationenergy modules

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Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Electrical Engineering

Background:

  • Neuromodulation devices offer therapeutic potential but often require secondary removal surgery.
  • Bioresorbable electrically-active neuromodulation devices (BEANDs) integrate degradable materials with electrical stimulation capabilities.
  • BEANDs aim to eliminate the need for explantation surgery after fulfilling their therapeutic role.

Purpose of the Study:

  • To review the material science and device engineering of BEANDs.
  • To highlight the critical role of energy management in BEAND functionality.
  • To outline future directions for clinical translation of BEAND technology.

Main Methods:

  • Review of literature on degradable materials (metals, natural/synthetic polymers) and their biological effects.
  • Analysis of functional material systems including conductors, semiconductors, and dielectrics for BEANDs.
  • Examination of core device modules for energy harvesting, storage, transmission, and regulation.

Main Results:

  • BEANDs require a careful balance between material performance and bioresorbability.
  • Multimodal energy management is crucial for precise and personalized neuromodulation.
  • Degradation pathways and biological effects of constituent materials are key considerations.

Conclusions:

  • BEANDs represent a promising technological paradigm for neurological disorder treatment.
  • Interdisciplinary integration and clinical translation are essential for advancing BEANDs.
  • Future research should focus on optimizing material selection and energy systems for clinical application.