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A biobehavioural and social-structural model of inflammation and executive function in pediatric chronic health

Kathryn P King1, Tori Humiston2, Marissa A Gowey3

  • 1Department of Psychology, University of Alabama-Birmingham, Birmingham, AL, USA.

Health Psychology Review
|December 29, 2022
PubMed

Insights

Pediatric chronic health conditions (CHCs) can worsen executive functioning (EF), and vice versa. Inflammation and social inequities may drive this harmful cycle, impacting children's health management.

Area of Science:

  • Pediatric Health
  • Neuroscience
  • Public Health

Background:

  • Chronic health conditions (CHCs) in children often impair executive functioning (EF).
  • Impaired EF negatively impacts the management of pediatric CHCs.
  • A bidirectional relationship exists between CHCs and EF, influenced by biobehavioral and social-structural factors.

Purpose of the Study:

  • To propose a model integrating biobehavioral (inflammation) and social-structural factors (inequity).
  • To understand the feedback loop linking CHC severity, EF challenges, and health behaviors.
  • To identify targets for intervention to mitigate CHC impacts on children and families.

Main Methods:

  • Literature review of biobehavioral and social-structural research.
  • Conceptual model development focusing on inflammation and EF.
  • Analysis of the interplay between CHCs, inflammation, EF, and health behaviors.

Main Results:

  • Inflammation may mediate the link between CHC severity, EF challenges, and reduced health behaviors.
  • Social and environmental inequities exacerbate inflammation, CHC severity, and EF difficulties.
  • A feedback loop is proposed where these factors mutually reinforce negative outcomes.

Conclusions:

  • A comprehensive model is needed to address the complex interplay of factors affecting children with CHCs.
  • Inflammation and EF are central to understanding and intervening in this cycle.
  • Actionable research and clinical strategies can be developed based on this integrated model.

Keywords:
Executive functionchronic health conditionshealth behaviourinflammationpediatric psychologysystemic inequity

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