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Updated: Aug 15, 2025

Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology
Published on: March 22, 2024
Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy
Nisha Maheshwari1, Alessandro Marone1, Mirella Altoé2
1New York University, Department of Biomedical Engineering, New York, United States.
Significance:
Due to the persistence of chronic wounds, a second surgical intervention is often necessary for patients with peripheral arterial disease (PAD) within a year of the first intervention. The dynamic vascular optical spectroscopy system (DVOS) may assist physicians in determining patient prognosis only a month after the first surgical intervention.
Aim:
We aim to assess the DVOS utility in characterizing wound healing in PAD patients after endovascular intervention.
Approach:
The DVOS used near-infrared light ( ) to record hemodynamic response to a cuff inflation in 14 PAD patients with lower limb ulcers immediately before, immediately after, and at a first follow-up 3 to 4 weeks after intervention. Ankle-brachial index (ABI) and arterial duplex ultrasound (A-DUS) measurements were obtained when possible.
Results:
The total hemoglobin plateau time differed significantly between patients with ulcers that reduced in size ( ) and patients with ulcers that did not ( ) 3 to 4 weeks after intervention ( ). Data correlated strongly (89% sensitivity, 100% specificity, and ) with long-term wound healing. ABI and A-DUS measurements were not statistically associated with wound healing.
Conclusions:
This pilot study demonstrates the potential of the DVOS to aid physicians in giving accurate long-term wound healing prognoses 1 month after intervention.
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