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Accelerated ageing is associated with increased COVID-19 severity and differences across ethnic groups may exist
Joshua Reeves1,2, Jaspal S Kooner3,4,5,6, Weihua Zhang1,3
1Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Frontiers in Public Health
|December 30, 2022
Summary
Accelerated ageing, not just chronological age, is linked to severe COVID-19 outcomes. Interventions targeting biological age may improve COVID-19 prognosis, warranting further research into anti-ageing therapies.
Area of Science:
- Gerontology
- Immunology
- Epidemiology
Background:
- Chronological age is a known COVID-19 risk factor, but biological age better predicts health.
- Heterogeneity in COVID-19 outcomes exists within age groups.
- Accelerated ageing may influence disease severity.
Purpose of the Study:
- To investigate the association between accelerated ageing and severe COVID-19 outcomes.
- To examine phenotypic age acceleration, telomere length, and facial ageing.
- To explore potential ethnic differences in these associations.
Main Methods:
- Utilized UK Biobank participants for a case-control study.
- Employed logistic regression models adjusting for covariates.
- Assessed associations within White, Black, Asian, and Other ethnic groups.
Main Results:
- Phenotypic age acceleration and younger facial age were associated with reduced odds of severe COVID-19.
- Chronological age remained a significant predictor, but its impact lessened when accounting for biological age markers.
- Phenotypic age acceleration showed significant associations in White and Black populations.
Conclusions:
- Accelerated ageing is linked to increased COVID-19 severity, potentially via immunosenescence and inflamaging.
- Anti-ageing interventions could improve COVID-19 outcomes.
- Further research is needed to clarify ethnic variations and the role of telomere length.
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