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Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

3.6K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Termination of Translation01:44

Termination of Translation

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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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Ribosomes01:27

Ribosomes

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Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Related Experiment Video

Updated: Aug 15, 2025

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
06:58

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling

Published on: October 7, 2021

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Modeling the ribosome as a bipartite graph.

Laurie E Calvet1

  • 1CNRS, Centre de Nanosciences et Nanotechnologies, Université Paris-Saclay, Palaiseau, France.

Plos One
|December 30, 2022
PubMed
Summary

This study models the ribosome, a protein-making machine, as a resilient bipartite network. This network representation reveals inherent mathematical redundancies, explaining its functional consistency and offering insights into translation regulation.

Area of Science:

  • Molecular Biology
  • Network Theory
  • Computational Biology

Background:

  • Developing predictive mathematical models for biological systems is crucial.
  • The ribosome is a vital cellular machine responsible for protein synthesis.

Purpose of the Study:

  • To represent the ribosome as a bipartite network.
  • To analyze the topological properties and resilience of ribosomal networks.

Main Methods:

  • Exploration of ten ribosomal structures from Bacteria and six from Eukarya.
  • Modeling these structures as bipartite networks.
  • Analysis of network properties, including topological redundancy.

Main Results:

  • Ribosomal networks exhibit unique properties despite structural variations.

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Last Updated: Aug 15, 2025

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
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  • Significant topological redundancies were identified, indicating mathematical resiliency.
  • This resilience may explain consistent ribosomal function despite compositional changes.

    • Conclusions:

    • The bipartite network model provides a novel framework for understanding ribosome structure and function.
    • This approach offers potential for new insights into translation regulation and therapeutic strategies.